RANDOMIZED TRIALS

  • A-DONUT

    Antibiotics for Older adults with No clear Urinary Tract Infection

    Multicentre pragmatic RCT evaluating the effectiveness of antibiotics for older adults with delirium and bacteriuria in the absence of symptoms of a UTI.

    clinicaltrials.gov

  • SNAP

    Staphylococcus Aureus Network Adaptive Platform

    Multicentre pragmatic, open-label RCT evaluating different treatment interventions based on 3 patterns of staphylococcus aureus susceptibility in adults.

    clinicaltrials.gov

  • BALANCE+

    BALANCE+: A Platform Trial for Gram Negative Bloodstream Infections

    A perpetual platform trial looking at best ways to ‘de-escalate’ and ‘step-down’ antibiotic treatment for patients with bloodstream infections caused by Gram negative bacteria.

    clinicaltrials.gov

Past RCTs

  • COVID-PRONE

    A multicentre pragmatic trial evaluating prone positioning (instructing a patient to lie on their stomach while they are in bed) versus standard of care (no instruction to adopt prone position).

    BMJ, 2022

  • RAPID COVID COAG

    A multicentre, open-label trial evaluating the effects of therapeutic heparin compared with prophylactic heparin among moderately ill hospitalized COVID-19 patients.

    BMJ, 2021

  • CONCOR-1

    Open-label, randomized controlled trial of convalescent plasma for adults with COVID-19 receiving oxygen within 12 days of respiratory symptom onset.

    Nat Med, 2021

  • CATCO/SOLIDARITY

    An international, open-label trial evaluating 4 drugs (remdesivir, hydroxychloroquine, lopinavir, and interferon beta-1a) on in-hospital mortality for hospitalized COVID-19 patients.

    NEJM, 2021

    Lancet, 2022

  • BALANCE

    An international, multicentre trial evaluating shorter (7 days) versus longer (14 days) antibiotic treatment among hospitalized patients with bloodstream infections.

    Trials, 2020